These medications are administered in eye drop form. A typical adrenergic drug called brimonidine tartrate, an eye-drop, bears a purplish cap.


If anyone needs to apply more than one kind of eye-drop, he may have to apply each drug in a specific order. A person may use the color of the cap to help him recall when to apply each kind of eye-drop.

In case you’re applying more than one kind of eye-drop, wait five minutes between the two eye-drop medicines. It is recommended to consult an eye doctor or visit an eye care center for processing eye exams before using any eye medication. A professional eye doctor can provide you primary vision care ranging from sight testing and correction to the diagnosis, treatment, and management of vision changes. You can visit your local Eye exam center to get started. 

Purpose of Adrenergic Agonists

Virtually all adrenergic agonists decrease the pressure in the eyeballs by limiting how much fluid (aqueous humor) the eyeballs contain. They also raise the level of fluid that runs out of the eyes.

These drugs may be taken in combination with other prescription drugs to deal with glaucoma.

Brimonidine and apraclonidine are given to care for excessive pressure in the eyeballs in individuals with chronic glaucoma. They are also prescribed to avoid excessive pressure inside the eye following laser therapy for glaucoma. For daily use, brimonidine (Alphagan) is becoming more popular than apraclonidine (Iopidine) since it is less likely to result in an allergy. A few drugstores no longer stock apraclonidine eye-drops.


Decreasing the pressure inside the eyeballs foreshortens the risks of injury to the optic tract, avoiding additional vision loss. Don’t forget filing a claim after a motor vehicle collision in Indiana to ensure a good legal case.

Dipivefrin is changed to epinephrine once it is inside a person. Since the latest adrenergic agonists are more efficient and have fewer side effects, dipivefrin is seldom given. Epinephrine is seldom prescribed because brimonidine and apraclonidine are just as potent with lesser side effects.

Side Effects of Adrenergic Agonists for Glaucoma

  • Inflammation and burning of the eyes.
  • Allergy in the eyes (severe itching).
  • Xerostomia (dry mouth) is somewhat common with the latest drugs but generally gets better over time.
  • Sleepiness, jumpiness, and headaches (cephalalgias).
  • Fast or atypical heartbeat.
  • Elevated blood pressure.

Adrenergic agonists (particularly epinephrine) can broaden and dilate the pupils. This may result in closed-angle glaucoma in individuals who have bad drainage from their eyes.

Brimonidine shouldn’t be taken if an individual is using a MAOI (monoamine oxidase inhibitor) medication for dealing with depression. Individuals who are using tricyclics and those with serious liver, heart, or kidney condition may not be allowed to use brimonidine.

Epinephrine drops constrain the blood vessels on the eyeball surface, bringing the red out of the white region of the eye. After two to three hours, the blood vessels dilate (expand) and the eye gets red once again. Unfortunately, patients might be tempted to abuse this drug in order to keep their eyes from turning red.

Brimonidine and apraclonidine can bring about allergy issues in certain individuals when taken over a long time.

These drugs should be used with care in older patients and persons who suffer from high blood pressure, diabetes, an overactive thyroid (hyperthyroidism), or cardiopathy (heart disease).

If you have other eye problems like myopia, hyperopia, and astigmatism, you can improve your vision by having laser eye surgery from an eye doctor.


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